The Role of Carbon Dioxide in the Rat Acute Stroke Penumbra

PurposeThe vasodilatory response to inhaled CO2 occurs in the acute stroke ischemic penumbra and may be a potential therapeutic modality.MethodsTwenty-two Sprague-Dawley rats were subjected to 90-min occlusion of the M2 segment of the middle cerebral artery (M2CAO) by endovascular technique. The ani...

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Bibliographic Details
Main Authors: Leonard L. Yeo, Fabian Arnberg, Arvin Chireh, Vijay Sharma, Benjamin Tan, Vamsi Gontu, Philip Little, Staffan Holmin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Digital Health
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fdgth.2021.824334/full