Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice

Summary: Adipose tissue browning and systemic energy expenditure provide a defense mechanism against obesity and associated metabolic diseases. In high-cholesterol Western diet-fed mice, mast cell (MC) inactivation ameliorates obesity and insulin resistance and improves the metabolic rate, but a dir...

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Bibliographic Details
Main Authors: Xian Zhang, Xin Wang, Hao Yin, Lei Zhang, Airong Feng, Qiu-Xia Zhang, Yan Lin, Bin Bao, Laura L. Hernandez, Guo-Ping Shi, Jian Liu
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719308174