A high-content screen reveals new regulators of nuclear membrane stability

Abstract Nuclear membrane rupture is a physiological response to multiple in vivo processes, such as cell migration, that can cause extensive genome instability and upregulate invasive and inflammatory pathways. However, the underlying molecular mechanisms of rupture are unclear and few regulators h...

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Bibliographic Details
Main Authors: Amanda L. Gunn, Artem I. Yashchenko, Julien Dubrulle, Jodiene Johnson, Emily M. Hatch
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-56613-1