YAP1 Is a Potential Predictive Molecular Biomarker for Response to SMO Inhibitor in Medulloblastoma Cells

YAP1 Is a Potential Predictive Molecular Biomarker for Response to SMO Inhibitor in Medulloblastoma Cells

Advances in genomics have led to the identification of twelve relevant molecular subtypes within medulloblastoma (MB). The alpha subtype of Sonic hedgehog-driven MB is resistant to therapy (including smoothened inhibitors) due to activation of genes from the non-canonical SHH pathway, such as <i&...

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Bibliographic Details
Main Authors: Gustavo Alencastro Veiga Cruzeiro, Taciani de Almeida Magalhães, Graziella Ribeiro de Sousa, Ricardo Bonfim Silva, Carlos Alberto Oliveira de Biagi Junior, Pablo Ferreira das Chagas, Rosane Gomes de Paula Queiroz, Carlos Alberto Scrideli, Luiz Gonzaga Tone, Elvis Terci Valera
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
SHH medulloblastoma
YAP1
SMO inhibitor
Online Access:https://www.mdpi.com/2072-6694/13/24/6249

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https://www.mdpi.com/2072-6694/13/24/6249

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