The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous <i>BRCA<sup>MUT</sup></i> and <i>BRCA<sup>WT</sup></i> Ovarian Cancer Cells

The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous <i>BRCA<sup>MUT</sup></i> and <i>BRCA<sup>WT</sup></i> Ovarian Cancer Cells

Olaparib is a poly (ADP-ribose) polymerase inhibitor (PARPi) that inhibits PARP1/2, leading to replication-induced DNA damage that requires homologous recombination repair. Olaparib is often insufficient to treat <i>BRCA</i>-mutated (<i>BRCA<sup>MUT</sup></i>) and...

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Bibliographic Details
Main Authors: Patrycja Gralewska, Arkadiusz Gajek, Dorota Rybaczek, Agnieszka Marczak, Aneta Rogalska
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
ATR inhibitor
CHK1 inhibitor
ovarian cancer
PARP inhibitor
replication stress
targeted therapy
Online Access:https://www.mdpi.com/2073-4409/11/12/1889

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https://www.mdpi.com/2073-4409/11/12/1889

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