Intracellular calcium ions facilitate dengue virus entry into endothelial cells and compromise endothelial barrier integrity

Intracellular calcium ions facilitate dengue virus entry into endothelial cells and compromise endothelial barrier integrity

Objective: To investigate the involvement of Ca2+ in dengue virus (DENV)-infected human umbilical vein endothelial cells (HUVECs) and the disruption of endothelial integrity. Methods: HUVECs were infected with DENV-2 in the presence of intracellular Ca2+ or endoplasmic reticulum Ca2+ chelators. Viru...

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Bibliographic Details
Main Authors: Meng-Hooi Shu, Pooi-Fong Wong, Sing-Sin Sam, Shih-Keng Loong, Boon-Teong Teoh, Sazaly AbuBakar
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Asian Pacific Journal of Tropical Medicine
Subjects:
endothelial cells; calcium signalling; dengue virus; endothelium permeability; intracellular calcium
Online Access:http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=11;spage=505;epage=516;aulast=Shu

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http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=11;spage=505;epage=516;aulast=Shu

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