Soluble CLEC2 Extracellular Domain Improves Glucose and Lipid Homeostasis by Regulating Liver Kupffer Cell Polarization

Soluble CLEC2 Extracellular Domain Improves Glucose and Lipid Homeostasis by Regulating Liver Kupffer Cell Polarization

The polarization of tissue resident macrophages toward the alternatively activated, anti-inflammatory M2 phenotype is believed to positively impact obesity and insulin resistance. Here we show that the soluble form of the extracellular domain (ECD) of C-type lectin-like receptor 2, CLEC2, regulates...

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Bibliographic Details
Main Authors: Xinle Wu, Jun Zhang, Hongfei Ge, Jamila Gupte, Helene Baribault, Ki Jeong Lee, Bryan Lemon, Suzanne Coberly, Yan Gong, Zheng Pan, Ingrid C. Rulifson, Jonitha Gardner, William G. Richards, Yang Li
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:EBioMedicine
Subjects:
CLEC2
Macrophage
Kupffer cell
Inflammation
Diabetes
Dyslipidemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415000614

Internet

http://www.sciencedirect.com/science/article/pii/S2352396415000614

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