RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia

RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia

RAS mutations are among the most prevalent oncogenic drivers in cancers. RAS proteins propagate signals only when associated with cellular membranes as a consequence of lipid modifications that impact their trafficking. Here, we discovered that RAB27B, a RAB family small GTPase, controlled NRAS palm...

Full description

Bibliographic Details
Main Authors: Jian-Gang Ren, Bowen Xing, Kaosheng Lv, Rachel A. O’Keefe, Mengfang Wu, Ruoxing Wang, Kaylyn M. Bauer, Arevik Ghazaryan, George M. Burslem, Jing Zhang, Ryan M. O’Connell, Vinodh Pillai, Elizabeth O. Hexner, Mark R. Philips, Wei Tong
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-06-01
Series:The Journal of Clinical Investigation
Subjects:
Cell biology
Hematology
Online Access:https://doi.org/10.1172/JCI165510

Internet

https://doi.org/10.1172/JCI165510

Similar Items