The critical role of membralin in postnatal motor neuron survival and disease

The critical role of membralin in postnatal motor neuron survival and disease

Hitherto, membralin has been a protein of unknown function. Here, we show that membralin mutant mice manifest a severe and early-onset motor neuron disease in an autosomal recessive manner, dying by postnatal day 5–6. Selective death of lower motor neurons, including those innervating the limbs, int...

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Bibliographic Details
Main Authors: Bo Yang, Mingliang Qu, Rengang Wang, Jon E Chatterton, Xiao-Bo Liu, Bing Zhu, Sonoko Narisawa, Jose Luis Millan, Nobuki Nakanishi, Kathryn Swoboda, Stuart A Lipton, Dongxian Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-05-01
Series:eLife
Subjects:
motor neuron disease
ER stress
ER membrane protein
Online Access:https://elifesciences.org/articles/06500

Internet

https://elifesciences.org/articles/06500

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