Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface

Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface

G protein-coupled receptors (GPCRs) are among the most promising drug targets. They often form homo- and heterodimers with allosteric cross-talk between receptor entities, which contributes to fine-tuning of transmembrane signaling. Specifically controlling the activity of GPCR dimers with ligands i...

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Bibliographic Details
Main Authors: Lei Liu, Zhiran Fan, Xavier Rovira, Li Xue, Salomé Roux, Isabelle Brabet, Mingxia Xin, Jean-Philippe Pin, Philippe Rondard, Jianfeng Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
oligomer
allosteric modulator
allosteric agonism
G protein
metabotropic glutamate receptor
GABA-B
Online Access:https://elifesciences.org/articles/70188

Internet

https://elifesciences.org/articles/70188

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