Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions

Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions

Tripartite motif (TRIM) family is assigned to RING-finger-containing ligases harboring the largest number of proteins in E3 ubiquitin ligating enzymes. E3 ubiquitin ligases target the specific substrate for proteasomal degradation via the ubiquitin–proteasome system (UPS), which seems to be a more e...

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Bibliographic Details
Main Authors: Jie Zhang, Yuting Zhou, Jiao Feng, Xuanfu Xu, Jianye Wu, Chuanyong Guo
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Tripartite motif
E3 ubiquitin ligase
Ubiquitin–proteasome system
Hepatocellular carcinoma
PROTAC
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223013367

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http://www.sciencedirect.com/science/article/pii/S0753332223013367

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