Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions
Tripartite motif (TRIM) family is assigned to RING-finger-containing ligases harboring the largest number of proteins in E3 ubiquitin ligating enzymes. E3 ubiquitin ligases target the specific substrate for proteasomal degradation via the ubiquitin–proteasome system (UPS), which seems to be a more e...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223013367 |
| _version_ | 1797660577702608896 |
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| author | Jie Zhang Yuting Zhou Jiao Feng Xuanfu Xu Jianye Wu Chuanyong Guo |
| author_facet | Jie Zhang Yuting Zhou Jiao Feng Xuanfu Xu Jianye Wu Chuanyong Guo |
| author_sort | Jie Zhang |
| collection | DOAJ |
| description | Tripartite motif (TRIM) family is assigned to RING-finger-containing ligases harboring the largest number of proteins in E3 ubiquitin ligating enzymes. E3 ubiquitin ligases target the specific substrate for proteasomal degradation via the ubiquitin–proteasome system (UPS), which seems to be a more effective and direct strategy for tumor therapy. Recent advances have demonstrated that TRIM genes associate with the occurrence and progression of hepatocellular carcinoma (HCC). TRIMs trigger or inhibit multiple biological activities like proliferation, apoptosis, metastasis, ferroptosis and autophagy in HCC dependent on its highly conserved yet diverse structures. Remarkably, autophagy is another proteolytic pathway for intracellular protein degradation and TRIM proteins may help to delineate the interaction between the two proteolytic systems. In depth research on the precise molecular mechanisms of TRIM family will allow for targeting TRIM in HCC treatment. We also highlight several potential directions warranted further development associated with TRIM family to provide bright insight into its translational values in hepatocellular carcinoma. |
| first_indexed | 2024-03-11T18:31:55Z |
| format | Article |
| id | doaj.art-63746bb00dae407ebb4ca6e7303f2b4a |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T18:31:55Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-63746bb00dae407ebb4ca6e7303f2b4a2023-10-13T11:03:00ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-11-01167115538Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directionsJie Zhang0Yuting Zhou1Jiao Feng2Xuanfu Xu3Jianye Wu4Chuanyong Guo5Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China; Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People's Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai 200072, ChinaDepartment of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China; Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China; Corresponding authors at: Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China.Department of Gastroenterology, Shidong Hospital, University of Shanghai for Science and Technology, Shanghai 200433, China; Corresponding authors.Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China; Corresponding authors.Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China; Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China; Corresponding authors at: Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China.Tripartite motif (TRIM) family is assigned to RING-finger-containing ligases harboring the largest number of proteins in E3 ubiquitin ligating enzymes. E3 ubiquitin ligases target the specific substrate for proteasomal degradation via the ubiquitin–proteasome system (UPS), which seems to be a more effective and direct strategy for tumor therapy. Recent advances have demonstrated that TRIM genes associate with the occurrence and progression of hepatocellular carcinoma (HCC). TRIMs trigger or inhibit multiple biological activities like proliferation, apoptosis, metastasis, ferroptosis and autophagy in HCC dependent on its highly conserved yet diverse structures. Remarkably, autophagy is another proteolytic pathway for intracellular protein degradation and TRIM proteins may help to delineate the interaction between the two proteolytic systems. In depth research on the precise molecular mechanisms of TRIM family will allow for targeting TRIM in HCC treatment. We also highlight several potential directions warranted further development associated with TRIM family to provide bright insight into its translational values in hepatocellular carcinoma.http://www.sciencedirect.com/science/article/pii/S0753332223013367Tripartite motifE3 ubiquitin ligaseUbiquitin–proteasome systemHepatocellular carcinomaPROTAC |
| spellingShingle | Jie Zhang Yuting Zhou Jiao Feng Xuanfu Xu Jianye Wu Chuanyong Guo Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions Biomedicine & Pharmacotherapy Tripartite motif E3 ubiquitin ligase Ubiquitin–proteasome system Hepatocellular carcinoma PROTAC |
| title | Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions |
| title_full | Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions |
| title_fullStr | Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions |
| title_full_unstemmed | Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions |
| title_short | Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions |
| title_sort | deciphering roles of trims as promising targets in hepatocellular carcinoma current advances and future directions |
| topic | Tripartite motif E3 ubiquitin ligase Ubiquitin–proteasome system Hepatocellular carcinoma PROTAC |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223013367 |
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