Lowering of Tumor Interstitial Fluid Pressure Reduces Tumor Cell Proliferation in a Xenograft Tumor Model

Lowering of Tumor Interstitial Fluid Pressure Reduces Tumor Cell Proliferation in a Xenograft Tumor Model

High tumor interstitial fluid pressure (TIFP) is a characteristic of most solid tumors. TIFP may hamper adequate uptake of macromolecular therapeutics in tumor tissue. In addition, TIFP generates mechanical forces affecting the tumor cortex, which might influence the growth parameters of tumor cells...

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Bibliographic Details
Main Authors: Matthias Hofmann, Maike Guschel, August Bernd, Jürgen Bereiter-Hahn, Roland Kaufmann, Christa Tandi, Helge Wiig, Stefan Kippenberger
Format: Article
Language:English
Published: Elsevier 2006-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Tumor interstitial fluid pressure
tumor cell proliferation
mechanical stimuli
p44/42 MAPK
Ki-67
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606801168

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http://www.sciencedirect.com/science/article/pii/S1476558606801168

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