Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients.

Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients.

We examined the constitutive function of the Ikaros (IK) transcription factor in blast cells from pediatric B-precursor acute lymphoblastic leukemia (BPL) patients using multiple assay platforms and bioinformatics tools. We found no evidence of diminished IK expression or function for primary cells...

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Bibliographic Details
Main Authors: Fatih M Uckun, Hong Ma, Rita Ishkhanian, Martha Arellano, Anoush Shahidzadeh, Amanda Termuhlen, Paul S Gaynon, Sanjive Qazi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3835424?pdf=render

Internet

http://europepmc.org/articles/PMC3835424?pdf=render

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