Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation

Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation

Atherosclerosis (AS) ultimately cause major adverse cardiovascular events (MACEs). While traditional strategies by lipid-reducing have reduced MACEs, many patients continue to face significant risks. It might attribute to the upregulation of CD47 expression in AS lesions, that mediated anti-efferocy...

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Bibliographic Details
Main Authors: Xiaozhi Hu, Yanyang Nan, Yuting Zhang, Jiajun Fan, Hanqi Wang, Yu Bai, Yuanzhen Zhang, Xuyao Zhang, Zeguo Zhu, Zhonglian Cao, Xiaomiao Ye, Tao Wu, Shuwen Xu, Zhengyu Wu, Wei Hu, Dianwen Ju
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmacological Research
Subjects:
Angiopoietin-like protein 3
CD47
Bifunctional protein
Atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004316

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http://www.sciencedirect.com/science/article/pii/S1043661824004316

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