Extracellular Matrix Changes in Subcellular Brain Fractions and Cerebrospinal Fluid of Alzheimer’s Disease Patients

Extracellular Matrix Changes in Subcellular Brain Fractions and Cerebrospinal Fluid of Alzheimer’s Disease Patients

The brain’s extracellular matrix (ECM) is assumed to undergo rearrangements in Alzheimer’s disease (AD). Here, we investigated changes of key components of the hyaluronan-based ECM in independent samples of post-mortem brains (N = 19), cerebrospinal fluids (CSF; N = 70), and RNAseq data (N = 107; fr...

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Bibliographic Details
Main Authors: Lukas Höhn, Wilhelm Hußler, Anni Richter, Karl-Heinz Smalla, Anna-Maria Birkl-Toeglhofer, Christoph Birkl, Stefan Vielhaber, Stefan L. Leber, Eckart D. Gundelfinger, Johannes Haybaeck, Stefanie Schreiber, Constanze I. Seidenbecher
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
aggrecan
brevican
cerebrospinal fluid/CSF
HAPLN1
neurocan
tenascin-R
Online Access:https://www.mdpi.com/1422-0067/24/6/5532

Internet

https://www.mdpi.com/1422-0067/24/6/5532

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