Metabolomic Signatures of Alzheimer’s Disease Indicate Brain Region-Specific Neurodegenerative Progression

Metabolomic Signatures of Alzheimer’s Disease Indicate Brain Region-Specific Neurodegenerative Progression

Pathological mechanisms contributing to Alzheimer’s disease (AD) are still elusive. Here, we identified the metabolic signatures of AD in human post-mortem brains. Using <sup>1</sup>H NMR spectroscopy and an untargeted metabolomics approach, we identified (1) metabolomic profiles of AD a...

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Bibliographic Details
Main Authors: Mirela Ambeskovic, Giselle Hopkins, Tanzi Hoover, Jeffrey T. Joseph, Tony Montina, Gerlinde A. S. Metz
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
proton nuclear magnetic resonance (<sup>1</sup>H NMR) spectroscopy
aging
neuropathology
neurodegenerative disease
cognitive function
phenylalanine
Online Access:https://www.mdpi.com/1422-0067/24/19/14769

Internet

https://www.mdpi.com/1422-0067/24/19/14769

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