Angiogenin mutations in Hungarian patients with amyotrophic lateral sclerosis: Clinical, genetic, computational, and functional analyses

Angiogenin mutations in Hungarian patients with amyotrophic lateral sclerosis: Clinical, genetic, computational, and functional analyses

Abstract Introduction Mutations in the angiogenin (ANG) gene are known to be associated with both familial and sporadic amyotrophic lateral sclerosis (ALS). The majority of disease‐causing mutations of ANG result in loss of either ribonucleolytic activity, nuclear translocation activity or both. Met...

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Bibliographic Details
Main Authors: Kornélia Tripolszki, Judit Danis, Aditya K. Padhi, James Gomes, Renáta Bozó, Zsófia F. Nagy, Dóra Nagy, Péter Klivényi, József I. Engelhardt, Márta Széll
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Brain and Behavior
Subjects:
amyotrophic lateral sclerosis
angiogenin
molecular dynamics
mutation screening
nuclear translocation
ribonucleolytic activity
Online Access:https://doi.org/10.1002/brb3.1293

Internet

https://doi.org/10.1002/brb3.1293

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