Synthesis of Novel 2-Thiouracil-5-Sulfonamide Derivatives as Potent Inducers of Cell Cycle Arrest and CDK2A Inhibition Supported by Molecular Docking

Synthesis of Novel 2-Thiouracil-5-Sulfonamide Derivatives as Potent Inducers of Cell Cycle Arrest and CDK2A Inhibition Supported by Molecular Docking

In an effort to discover potent anticancer agents, 2-thiouracil-5-sulfonamides derivatives were designed and synthesized. The cytotoxic activity of all synthesized compounds was investigated against four human cancer cell lines viz A-2780 (ovarian), HT-29 (colon), MCF-7 (breast), and HepG2 (liver)....

Full description

Bibliographic Details
Main Authors: Samar S. Fatahala, Amira I. Sayed, Shahenda Mahgoub, Heba Taha, Mohamed-I kotb El-Sayed, Mohamed F. El-Shehry, Samir M. Awad, Rania H. Abd El-Hameed
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
sulfonamides
cytotoxicity
apoptosis
cell cycle
CDK2
molecular docking
Online Access:https://www.mdpi.com/1422-0067/22/21/11957

Internet

https://www.mdpi.com/1422-0067/22/21/11957

Similar Items