A Nonsense Variant in <i>CCDC65</i> Gene Causes Respiratory Failure Associated with Increased Lamb Mortality in French Lacaune Dairy Sheep

A Nonsense Variant in <i>CCDC65</i> Gene Causes Respiratory Failure Associated with Increased Lamb Mortality in French Lacaune Dairy Sheep

We recently demonstrated that the Lacaune deficient homozygous haplotype 6 (LDHH6) potentially hosts a recessive perinatal lethal mutation in Lacaune dairy sheep mapped on OAR3. In the present study, we have analyzed the whole-genome sequences of two Lacaune ram heterozygous carriers of LDHH6. After...

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Bibliographic Details
Main Authors: Maxime Ben Braiek, Carole Moreno-Romieux, Charlotte Allain, Philippe Bardou, Arnaud Bordes, Frédéric Debat, Cord Drögemüller, Florence Plisson-Petit, David Portes, Julien Sarry, Némuel Tadi, Florent Woloszyn, Stéphane Fabre
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Genes
Subjects:
homozygous haplotype deficiency
LDHH6
CCDC65
juvenile lethal mutation
genetic disorder
primary cilia dyskinesia (PCD)
Online Access:https://www.mdpi.com/2073-4425/13/1/45

Internet

https://www.mdpi.com/2073-4425/13/1/45

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