Metformin Protects Neurons against Oxygen-Glucose Deprivation/Reoxygenation -Induced Injury by Down-Regulating MAD2B

Metformin Protects Neurons against Oxygen-Glucose Deprivation/Reoxygenation -Induced Injury by Down-Regulating MAD2B

Background/Aims: Metformin, the common medication for type II diabetes, has protective effects on cerebral ischemia. However, the molecular mechanisms are far from clear. Mitotic arrest deficient 2-like protein 2 (MAD2B), an inhibitor of the anaphase-promoting complex (APC), is widely expressed in h...

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Bibliographic Details
Main Authors: Xianfang Meng, Guangpin Chu, Zhihua Yang, Ping Qiu, Yue Hu, Xiaohe Chen, Wenpeng Peng, Chen Ye, Fang-Fang He, Chun Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Metformin
Oxygen-glucose deprivation/reoxygenation
MAD2B
Cyclin B1
Histone 3
Online Access:http://www.karger.com/Article/FullText/452562

Internet

http://www.karger.com/Article/FullText/452562

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