Nicorandil inhibits cardiomyocyte apoptosis and improves cardiac function by suppressing the HtrA2/XIAP/PARP signaling after coronary microembolization in rats

Nicorandil inhibits cardiomyocyte apoptosis and improves cardiac function by suppressing the HtrA2/XIAP/PARP signaling after coronary microembolization in rats

Abstract Cardiomyocyte apoptosis is a key factor in the deterioration of cardiac function after coronary microembolization (CME). Nicorandil (NIC) affects myocardial injury, which may be related to the inhibition of apoptosis. However, the specific mechanism of cardioprotection has not been elucidat...

Full description

Bibliographic Details
Main Authors: Jing Zheng, Manyun Long, Zhenbai Qin, Fen Wang, Zhiqing Chen, Lang Li
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Pharmacology Research & Perspectives
Subjects:
apoptosis
coronary microembolization
HtrA2
nicorandil
PARP
XIPA
Online Access:https://doi.org/10.1002/prp2.699

Internet

https://doi.org/10.1002/prp2.699

Similar Items