Humanized <i>Dsp</i> ACM Mouse Model Displays Stress-Induced Cardiac Electrical and Structural Phenotypes

Humanized <i>Dsp</i> ACM Mouse Model Displays Stress-Induced Cardiac Electrical and Structural Phenotypes

Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by fibro-fatty infiltration with an increased propensity for ventricular arrhythmias and sudden death. Genetic variants in desmosomal genes are associated with ACM. Incomplete penetrance is a common feature in ACM families, c...

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Bibliographic Details
Main Authors: Tyler L. Stevens, Heather R. Manring, Michael J. Wallace, Aaron Argall, Trevor Dew, Peter Papaioannou, Steve Antwi-Boasiako, Xianyao Xu, Stuart G. Campbell, Fadi G. Akar, Maegen A. Borzok, Thomas J. Hund, Peter J. Mohler, Sara N. Koenig, Mona El Refaey
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
desmoplakin
arrhythmogenic cardiomyopathy
arrhythmia
mouse model
intercalated disc
cardiac stress
Online Access:https://www.mdpi.com/2073-4409/11/19/3049

Internet

https://www.mdpi.com/2073-4409/11/19/3049

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