Diastereoselective Synthesis of the Borylated <span style="font-variant: small-caps">d</span>-Galactose Monosaccharide 3-Boronic-3-Deoxy-<span style="font-variant: small-caps">d</span>-Galactose and Biological Evaluation in Glycosidase Inhibition and in Cancer for Boron Neutron Capture Therapy (BNCT)

Diastereoselective Synthesis of the Borylated <span style="font-variant: small-caps">d</span>-Galactose Monosaccharide 3-Boronic-3-Deoxy-<span style="font-variant: small-caps">d</span>-Galactose and Biological Evaluation in Glycosidase Inhibition and in Cancer for Boron Neutron Capture Therapy (BNCT)

Drug leads with a high Fsp<sup>3</sup> index are more likely to possess desirable properties for progression in the drug development pipeline. This paper describes the development of an efficient two-step protocol to completely diastereoselectively access a diethanolamine (DEA) boronate...

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Bibliographic Details
Main Author: Michela I. Simone
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
<span style="font-variant: small-caps">d</span>-galactose
boronic acid
boronate
organic boron
BNCT
glycosidase
Online Access:https://www.mdpi.com/1420-3049/28/11/4321

Internet

https://www.mdpi.com/1420-3049/28/11/4321

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