CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer.

CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer.

The induction of polyploidy is considered the reproductive end of cells, but there is evidence that polyploid giant cancer cells (PGCCs) contribute to cell repopulation during tumor relapse. However, the role of these cells in the development, progression and response to therapy in colon cancer rema...

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Bibliographic Details
Main Authors: Laura M Lopez-Sánchez, Carla Jimenez, Araceli Valverde, Vanessa Hernandez, Jon Peñarando, Antonio Martinez, Chary Lopez-Pedrera, Juan R Muñoz-Castañeda, Juan R De la Haba-Rodríguez, Enrique Aranda, Antonio Rodriguez-Ariza
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24932611/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24932611/pdf/?tool=EBI

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