Crystal structures of Triosephosphate Isomerases from Taenia solium and Schistosoma mansoni provide insights for vaccine rationale and drug design against helminth parasites.

Crystal structures of Triosephosphate Isomerases from Taenia solium and Schistosoma mansoni provide insights for vaccine rationale and drug design against helminth parasites.

Triosephosphate isomerases (TPIs) from Taenia solium (TsTPI) and Schistosoma mansoni (SmTPI) are potential vaccine and drug targets against cysticercosis and schistosomiasis, respectively. This is due to the dependence of parasitic helminths on glycolysis and because those proteins elicit an immune...

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Bibliographic Details
Main Authors: Pedro Jimenez-Sandoval, Eduardo Castro-Torres, Rogelio González-González, Corina Díaz-Quezada, Misraim Gurrola, Laura D Camacho-Manriquez, Lucia Leyva-Navarro, Luis G Brieba
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0007815

Internet

https://doi.org/10.1371/journal.pntd.0007815

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