Strategies for enhancing CAR T cell expansion and persistence in HIV infection

Strategies for enhancing CAR T cell expansion and persistence in HIV infection

Chimeric Antigen Receptor (CAR) T cell therapies are tremendously successful in hematological malignancies and show great promise as treatment and curative strategy for HIV. A major determinant for effective CAR T cell therapy is the persistence of CAR T cells. Particularly, antigen density and targ...

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Bibliographic Details
Main Authors: Frederik Holm Rothemejer, Nanna Pi Lauritsen, Ole Schmeltz Søgaard, Martin Tolstrup
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor
HIV
persistence
expansion
TCR-engagement
CAR T cell persistence
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1253395/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1253395/full

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