Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity

Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity

According to the “hydrodynamic theory,” dentinal pain or sensitivity is caused by dentinal fluid movement following the application of various stimuli to the dentin surface. Recent convergent evidence in Vitro has shown that plasma membrane deformation, mimicking dentinal fluid movement, activates m...

Full description

Bibliographic Details
Main Authors: Sadao Ohyama, Takehito Ouchi, Maki Kimura, Ryuya Kurashima, Keiko Yasumatsu, Daisuke Nishida, Suzuro Hitomi, Sobhan Ubaidus, Hidetaka Kuroda, Shinichirou Ito, Masayuki Takano, Kentaro Ono, Toshihide Mizoguchi, Akira Katakura, Yoshiyuki Shibukawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Physiology
Subjects:
dental pain
dentin hypersensitivity
odontoblasts
pannexin channels
piezo channels
P2X receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.891759/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.891759/full

Similar Items