Apoptosis Detection in Retinal Ganglion Cells Using Quantitative Changes in Multichannel Fluorescence Colocalization

Apoptosis Detection in Retinal Ganglion Cells Using Quantitative Changes in Multichannel Fluorescence Colocalization

KcapTR488 is a dual-fluorophore peptide sensor for the real-time reporting of programmed cell death by fluorescence imaging. KcapTR488 contains a nuclear localization sequence (NLS) conjugated with Texas Red, a caspase-cleavable sequence (DEVD), and a C-terminus conjugated to Alexa Fluor 488 (AF488)...

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Bibliographic Details
Main Authors: Xudong Qiu, Seth T. Gammon, James R. Johnson, Federica Pisaneschi, Steven W. Millward, Edward M. Barnett, David Piwnica-Worms
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biosensors
Subjects:
apoptosis
retinal ganglion cell
dual-fluorophore peptide sensor
fluorescence resonance energy transfer
NMDA
anterograde axonal transport
Online Access:https://www.mdpi.com/2079-6374/12/9/693

Internet

https://www.mdpi.com/2079-6374/12/9/693

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