Exploring Dried Blood Spot Cortisol Concentrations as an Alternative for Monitoring Pediatric Adrenal Insufficiency Patients: A Model-Based Analysis

Exploring Dried Blood Spot Cortisol Concentrations as an Alternative for Monitoring Pediatric Adrenal Insufficiency Patients: A Model-Based Analysis

Congenital adrenal hyperplasia (CAH) is the most common form of adrenal insufficiency in childhood; it requires cortisol replacement therapy with hydrocortisone (HC, synthetic cortisol) from birth and therapy monitoring for successful treatment. In children, the less invasive dried blood spot (DBS)...

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Bibliographic Details
Main Authors: Viktoria Stachanow, Uta Neumann, Oliver Blankenstein, Davide Bindellini, Johanna Melin, Richard Ross, Martin J. Whitaker, Wilhelm Huisinga, Robin Michelet, Charlotte Kloft
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
adrenal insufficiency
cortisol
dried blood spots
pediatrics
pharmacokinetics
binding
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.819590/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.819590/full

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