Interference With Coagulation Cascade as a Novel Approach to Counteract Cisplatin-Induced Acute Tubular Necrosis; an Experimental Study in Rats

Interference With Coagulation Cascade as a Novel Approach to Counteract Cisplatin-Induced Acute Tubular Necrosis; an Experimental Study in Rats

Coagulation system activation plays an important role in the pathophysiology of different diseases. In spite of massive research regarding cisplatin-induced nephrotoxicity, the role of coagulation cascade in such toxicity is still questionable. Here, we aim to investigate the role of activation of c...

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Bibliographic Details
Main Authors: Mohamed G. Ewees, Basim A. S. Messiha, Ali A. Abo-Saif, Asmaa M. A. Bayoumi, Mohamed S. Abdel-Bakky
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
coagulation cascade
cisplatin
rivaroxaban
fibrin
tissue factor
nephrotoxicity
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01155/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01155/full

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