A genome editing approach to study cancer stem cells in human tumors

A genome editing approach to study cancer stem cells in human tumors

Abstract The analysis of stem cell hierarchies in human cancers has been hampered by the impossibility of identifying or tracking tumor cell populations in an intact environment. To overcome this limitation, we devised a strategy based on editing the genomes of patient‐derived tumor organoids using...

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Bibliographic Details
Main Authors: Carme Cortina, Gemma Turon, Diana Stork, Xavier Hernando‐Momblona, Marta Sevillano, Mònica Aguilera, Sébastien Tosi, Anna Merlos‐Suárez, Camille Stephan‐Otto Attolini, Elena Sancho, Eduard Batlle
Format: Article
Language:English
Published: Springer Nature 2017-05-01
Series:EMBO Molecular Medicine
Subjects:
cancer stem cells
colorectal cancer
CRISPR/Cas9
LGR5
Online Access:https://doi.org/10.15252/emmm.201707550

Internet

https://doi.org/10.15252/emmm.201707550

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