Neoantigen-specific TCR-T cell-based immunotherapy for acute myeloid leukemia
Abstract Neoantigens derived from non-synonymous somatic mutations are restricted to malignant cells and are thus considered ideal targets for T cell receptor (TCR)-based immunotherapy. Adoptive transfer of T cells bearing neoantigen-specific TCRs exhibits the ability to preferentially target tumor...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2022-11-01
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Series: | Experimental Hematology & Oncology |
Online Access: | https://doi.org/10.1186/s40164-022-00353-3 |