Neoantigen-specific TCR-T cell-based immunotherapy for acute myeloid leukemia

Neoantigen-specific TCR-T cell-based immunotherapy for acute myeloid leukemia

Abstract Neoantigens derived from non-synonymous somatic mutations are restricted to malignant cells and are thus considered ideal targets for T cell receptor (TCR)-based immunotherapy. Adoptive transfer of T cells bearing neoantigen-specific TCRs exhibits the ability to preferentially target tumor...

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Bibliographic Details
Main Authors: Weijun Zhou, Jinyi Yu, Yilu Li, Kankan Wang
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Experimental Hematology & Oncology
Online Access:https://doi.org/10.1186/s40164-022-00353-3

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