Analysis of the Effects of Pentose Phosphate Pathway Inhibition on the Generation of Reactive Oxygen Species and Epileptiform Activity in Hippocampal Slices

Analysis of the Effects of Pentose Phosphate Pathway Inhibition on the Generation of Reactive Oxygen Species and Epileptiform Activity in Hippocampal Slices

The pentose phosphate pathway (PPP) is one of three major pathways involved in glucose metabolism, which is regulated by glucose-6-phosphate dehydrogenase (G6PD) controls NADPH formation. NADPH, in turn, regulates the balance of oxidative stress and reactive oxygen species (ROS) levels. G6PD dysfunc...

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Bibliographic Details
Main Authors: Daria Ponomareva, Anton Ivanov, Piotr Bregestovski
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
pentose phosphate pathway
glucose-6-phosphate dehydrogenase
glucose metabolism
reactive oxygen species
H<sub>2</sub>O<sub>2</sub> release
epilepsy
Online Access:https://www.mdpi.com/1422-0067/25/3/1934

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https://www.mdpi.com/1422-0067/25/3/1934

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