Cdk12 maintains the integrity of adult axons by suppressing actin remodeling

Cdk12 maintains the integrity of adult axons by suppressing actin remodeling

Abstract The role of cyclin-dependent kinases (CDKs) that are ubiquitously expressed in the adult nervous system remains unclear. Cdk12 is enriched in terminally differentiated neurons where its conical role in the cell cycle progression is redundant. We find that in adult neurons Cdk12 acts a negat...

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Bibliographic Details
Main Authors: L. N. Townsend, H. Clarke, D. Maddison, K. M. Jones, L. Amadio, A. Jefferson, U. Chughtai, D. M. Bis, S. Züchner, N. D. Allen, W. Van der Goes van Naters, O. M. Peters, G. A. Smith
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01642-4

Internet

https://doi.org/10.1038/s41420-023-01642-4

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