Targeting Antiapoptotic Bcl-2 Family Members with Cell-Permeable BH3 Peptides Induces Apoptosis Signaling, Death in Head, Neck Squamous Cell Carcinoma Cells

Targeting Antiapoptotic Bcl-2 Family Members with Cell-Permeable BH3 Peptides Induces Apoptosis Signaling, Death in Head, Neck Squamous Cell Carcinoma Cells

Head, neck squamous cell carcinomas (HNSCCs) are frequently characterized by chemotherapy, radiation resistance, by overexpression of Bcl-XL, an antiapoptotic member of the Bcl-2 protein family. In this report, we examined whether cell-permeable peptides derived from the BH3 domains of proapoptotic...

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Bibliographic Details
Main Authors: Rongxiu Li, Amanda L. Boehm, Michelle B. Miranda, Sanjeev Shangary, Jennifer R. Grandis, Daniel E Johnson
Format: Article
Language:English
Published: Elsevier 2007-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
HNSCC
Bcl-XL
Bcl-2
BH3 peptides
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800601

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http://www.sciencedirect.com/science/article/pii/S1476558607800601

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