A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.

Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within intron 1 influence upstream or downstream genes. We...

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Bibliographic Details
Main Authors: Chris Church, Sheena Lee, Eleanor A L Bagg, James S McTaggart, Robert Deacon, Thomas Gerken, Angela Lee, Lee Moir, Jasmin Mecinović, Mohamed M Quwailid, Christopher J Schofield, Frances M Ashcroft, Roger D Cox
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2719869?pdf=render

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http://europepmc.org/articles/PMC2719869?pdf=render

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