The BDNF-TrkB Pathway Acts Through Nucleus Accumbens D2 Expressing Neurons to Mediate Stress Susceptible Outcomes

The BDNF-TrkB Pathway Acts Through Nucleus Accumbens D2 Expressing Neurons to Mediate Stress Susceptible Outcomes

Brain-derived neurotrophic factor (BDNF) has a critical role in stress response including neuropsychiatric disorders that are precipitated by stress, such as major depressive disorder (MDD). BDNF acts through its full-length BDNF receptor tyrosine kinase B (TrkB) to trigger a pro-plasticity effect....

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Bibliographic Details
Main Authors: Marco Pagliusi, Daniela Franco, Shannon Cole, Gessynger Morais-Silva, Ramesh Chandra, Megan E. Fox, Sergio D. Iñiguez, Cesar R. Sartori, Mary Kay Lobo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Psychiatry
Subjects:
medium spiny neurons
social defeat stress
witness defeat
depression
resilience
nucleus accumbens (NAc)
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.854494/full

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https://www.frontiersin.org/articles/10.3389/fpsyt.2022.854494/full

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