Disturbed nitric oxide signalling gives rise to congenital bicuspid aortic valve and aortopathy

Disturbed nitric oxide signalling gives rise to congenital bicuspid aortic valve and aortopathy

Patients with a congenital bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, have an increased risk of developing thoracic aneurysms and aortic dissection. The mechanisms underlying BAV-associated aortopathy are poorly understood. This study examined BAV-associated aort...

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Bibliographic Details
Main Authors: Joshua C. Peterson, Lambertus J. Wisse, Valerie Wirokromo, Tessa van Herwaarden, Anke M. Smits, Adriana C. Gittenberger-de Groot, Marie-José T. H. Goumans, J. Conny VanMunsteren, Monique R. M. Jongbloed, Marco C. DeRuiter
Format: Article
Language:English
Published: The Company of Biologists 2020-09-01
Series:Disease Models & Mechanisms
Subjects:
nos3
aortic dissection
bicuspid aortic valve
nitric oxide
development
congenital heart disease
Online Access:http://dmm.biologists.org/content/13/9/dmm044990

Internet

http://dmm.biologists.org/content/13/9/dmm044990

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