Lethal adulthood myelin breakdown by oligodendrocyte-specific Ddx54 knockout

Lethal adulthood myelin breakdown by oligodendrocyte-specific Ddx54 knockout

Summary: Multiple sclerosis (MS) is a leading disease that causes disability in young adults. We have previously shown that a DEAD-box RNA helicase Ddx54 binds to mRNA and protein isoforms of myelin basic protein (MBP) and that Ddx54 siRNA blocking abrogates oligodendrocyte migration and myelination...

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Bibliographic Details
Main Authors: Hiroaki Oizumi, Yuki Miyamoto, Chika Seiwa, Masahiro Yamamoto, Nozomu Yoshioka, Seiichi Iizuka, Tomohiro Torii, Katsuya Ohbuchi, Kazushige Mizoguchi, Junji Yamauchi, Hiroaki Asou
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Biological sciences
Neuroscience
Molecular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223015250

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http://www.sciencedirect.com/science/article/pii/S2589004223015250

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