Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response

Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response

A mathematical model of the human immunodeficiency virus Type 1 (HIV-1) life cycle in CD4 T cells was constructed and calibrated. It describes the activation of the intracellular Type I interferon (IFN-I) response and the IFN-induced suppression of viral replication. The model includes viral replica...

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Bibliographic Details
Main Authors: Igor Sazonov, Dmitry Grebennikov, Rostislav Savinkov, Arina Soboleva, Kirill Pavlishin, Andreas Meyerhans, Gennady Bocharov
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
HIV life cycle
Type I interferon (IFN-I)
viral dynamics
mathematical model
stochastic processes
Markov chain Monte Carlo method
Online Access:https://www.mdpi.com/1999-4915/15/2/296

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https://www.mdpi.com/1999-4915/15/2/296

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