Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model

Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model

IntroductionNadofaragene firadenovec (Ad-IFNα/Syn3) is now approved for BCG-unresponsive bladder cancer (BLCA). IFNα is a pleiotropic cytokine that causes direct tumor cell killing via TRAIL-mediated apoptosis, angiogenesis inhibition, and activation of the innate and adaptive immune system. We esta...

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Bibliographic Details
Main Authors: Alexis R. Steinmetz, Morgan Pierce, Alberto Martini, Come Tholomier, Ganiraju Manyam, Yan Chen, Akshay Sood, Jonathan J. Duplisea, Burles A. Johnson, Bogdan A. Czerniak, Byron H. Lee, Chinnaswamy Jagannath, Seppo Yla-Herttuala, Nigel R. Parker, David J. McConkey, Colin P. Dinney, Sharada Mokkapati
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
nadofaragene
gene therapy
interferon α
bladder cancer
single-cell RNA sequencing
cytokine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1387229/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1387229/full

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