A tumor-restricted glycoform of podocalyxin is a highly selective marker of immunologically cold high-grade serous ovarian carcinoma

A tumor-restricted glycoform of podocalyxin is a highly selective marker of immunologically cold high-grade serous ovarian carcinoma

IntroductionTargeted-immunotherapies such as antibody-drug conjugates (ADC), chimeric antigen receptor (CAR) T cells or bispecific T-cell engagers (eg, BiTE®) all aim to improve cancer treatment by directly targeting cancer cells while sparing healthy tissues. Success of these therapies requires tum...

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Bibliographic Details
Main Authors: Julyanne Brassard, Michael R. Hughes, Pamela Dean, Diana Canals Hernaez, Shelby Thornton, Allyson C. Banville, Julian Smazynski, Mary Warren, Kevin Zhang, Katy Milne, C. Blake Gilks, Anne-Marie Mes-Masson, David G. Huntsman, Brad H. Nelson, Calvin D. Roskelley, Kelly M. McNagny
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Oncology
Subjects:
podocalyxin
glycoepitope
immune cold
high-grade serous ovarian carcinoma
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1286754/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1286754/full

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