Caspase-3 Activation Correlates With the Initial Mitochondrial Membrane Depolarization in Neonatal Cerebellar Granule Neurons

Caspase-3 Activation Correlates With the Initial Mitochondrial Membrane Depolarization in Neonatal Cerebellar Granule Neurons

In this study we evaluated the effect of the reduction in the endoplasmic reticulum calcium concentration ([Ca2+]ER), changes in the cytoplasmic calcium concentration ([Ca2+]i), alteration of the mitochondrial membrane potential, and the ER stress in the activation of caspase-3 in neonatal cerebella...

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Bibliographic Details
Main Authors: Edaena Benítez-Rangel, Mauricio Olguín-Albuerne, María Cristina López-Méndez, Guadalupe Domínguez-Macouzet, Agustín Guerrero-Hernández, Julio Morán
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
neuronal death
cerebellar granule neurons
calcium
endoplasmic reticulum
mitochondria
endoplasmic reticulum stress
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00544/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00544/full

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