Nicotinamide mononucleotide attenuates HIF-1α activation and fibrosis in hypoxic adipose tissue via NAD+/SIRT1 axis

Nicotinamide mononucleotide attenuates HIF-1α activation and fibrosis in hypoxic adipose tissue via NAD+/SIRT1 axis

BackgroundFibrosis is increasingly considered as a major contributor in adipose tissue dysfunction. Hypoxic activation of hypoxia-inducible factor 1α (HIF-1α) induces a profibrotic transcription, leading to adipose fibrosis. Nicotinamide mononucleotide (NMN), a member of the vitamin B3 family, has b...

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Bibliographic Details
Main Authors: Keke Wu, Biao Li, Yingxu Ma, Tao Tu, Qiuzhen Lin, Jiayi Zhu, Yong Zhou, Na Liu, Qiming Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Endocrinology
Subjects:
nicotinamide mononucleotide
adipose tissue fibrosis
inflammation
HIF-1α activation
NAD +/SIRT1 axis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1099134/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1099134/full

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