Beta-Boswellic Acid Reverses 3-Nitropropionic Acid-Induced Molecular, Mitochondrial, and Histopathological Defects in Experimental Rat Model of Huntington’s Disease

Beta-Boswellic Acid Reverses 3-Nitropropionic Acid-Induced Molecular, Mitochondrial, and Histopathological Defects in Experimental Rat Model of Huntington’s Disease

Huntington’s disease (HD) is distinguished by a triple repeat of CAG in exon 1, an increase in poly Q in the Htt gene, and a loss of GABAergic medium spiny neurons (MSN) in the striatum and white matter of the cortex. Mitochondrial ETC-complex dysfunctions are involved in the pathogenesis of HD, inc...

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Bibliographic Details
Main Authors: Thamer H. Albekairi, Arzoo Kamra, Sudeep Bhardwaj, Sidharth Mehan, Aditi Giri, Manisha Suri, Abdulrahman Alshammari, Metab Alharbi, Abdullah F. Alasmari, Acharan S Narula, Reni Kalfin
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomedicines
Subjects:
β-Boswellic acid (β-BA)
Huntington’s disease (HD)
mitochondrial ETC-complexes
3-nitropropionic acid (3-NP)
neuroprotection
Online Access:https://www.mdpi.com/2227-9059/10/11/2866

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https://www.mdpi.com/2227-9059/10/11/2866

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