Sodium aescinate alleviates neuropathic pain through suppressing OGT-mediated O-GlcNAc modification of TLR3 to inactivate MAPK signaling pathway

Sodium aescinate alleviates neuropathic pain through suppressing OGT-mediated O-GlcNAc modification of TLR3 to inactivate MAPK signaling pathway

Neuropathic pain results from damage to nerves or the brain, and is characterized by symptoms such as allodynia, spontaneous pain, and hyperalgesia. The causes of this type of pain are intricate, which can make it difficult to treat. Sodium aescinate (SA), a natural extract from horse chestnut tree...

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Bibliographic Details
Main Authors: Rong Chen, Jiantao Hu, Yang Zhang, Yang Liu, Liujian Cao, Fan He, Qin Wang, Ying Chen, Shengwei Zhang, Songjiang Tang, Baojun Min
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Brain Research Bulletin
Subjects:
SA
Neuropathic pain
Microglia activation
MAPK pathway
O-GlcNAc
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923024002119

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http://www.sciencedirect.com/science/article/pii/S0361923024002119

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