Itaconic acid induces angiogenesis and suppresses apoptosis via Nrf2/autophagy to prolong the survival of multi-territory perforator flaps

Itaconic acid induces angiogenesis and suppresses apoptosis via Nrf2/autophagy to prolong the survival of multi-territory perforator flaps

Background: Perforator flaps are widely used in hand microsurgery to reconstruct and repair soft tissue injuries. However, ischemia and subsequent ischemia-reperfusion injury may cause distal necrosis of the flap. Itaconic acid (IA) is a modulator of macrophage function, which exerts anti-inflammato...

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Bibliographic Details
Main Authors: Gaojie Luo, Zekun Zhou, Chengxiong Huang, Peiyao Zhang, Nianzhe Sun, Wei Chen, Chao Deng, Xiaoxiao Li, Panfeng Wu, Juyu Tang, Liming Qing
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Heliyon
Subjects:
Apoptosis
Angiogenesis
Autophagy
Perforator flap
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023051174

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http://www.sciencedirect.com/science/article/pii/S2405844023051174

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