Intraocular human cytomegaloviruses of ocular diseases are distinct from those of viremia and are capable of escaping from innate and adaptive immunity by exploiting HLA-E-mediated peripheral and central tolerance

Intraocular human cytomegaloviruses of ocular diseases are distinct from those of viremia and are capable of escaping from innate and adaptive immunity by exploiting HLA-E-mediated peripheral and central tolerance

Human cytomegalovirus (HCMV) infections develop into CMV diseases that result in various forms of manifestations in local organs. CMV-retinitis is a form of CMV disease that develops in immunocompromised hosts with CMV-viremia after viruses in the peripheral circulation have entered the eye. In the...

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Main Authors: Mariko Shirane, Nobuyo Yawata, Daisuke Motooka, Kensuke Shibata, Seik-Soon Khor, Yosuke Omae, Toshikatsu Kaburaki, Ryoji Yanai, Hisashi Mashimo, Satoshi Yamana, Takako Ito, Akira Hayashida, Yasuo Mori, Akihiko Numata, Yusuke Murakami, Kohta Fujiwara, Nobuyuki Ohguro, Mayumi Hosogai, Masato Akiyama, Eiichi Hasegawa, Michael Paley, Atsunobu Takeda, Katsumi Maenaka, Koichi Akashi, Wayne M. Yokoyama, Katsushi Tokunaga, Makoto Yawata, Koh-Hei Sonoda
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
human cytomegalovirus
HLA-E
UL40
natural killer cells
HLA class I
NKG2A
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008220/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008220/full

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